RESUMO
Present work was conducted to study of role of NGAL in diagnosis and staging the severity of diabetic nephropathy in type 2 diabetes mellitus patients to assess serum NGAL, urine albumin levels in diabetic patients with and without apparent nephropathy. MATERIAL: Comparative study conducted in the General Medicine department of SMS Hospital. INCLUSION CRITERIA: Patients of type 2 Diabetes mellitus. EXCLUSION CRITERIA: Patients consuming high protein diet, pregnancy, severe muscular exercises, orthostatic albuminuria, congestive heart failure, urinary tract infections, liver diseases. Patients with type 1 diabetes mellitus. OBSERVATION: The mean age of patient was 51.7 years. Here, HbA1c and NGAL were negatively correlated with each other with Pearson correlation -0.484 (p-value<0.05). In prediabetic patients mean NGAL was 407ng/ml and as HbA1c increases mean NGAL decreases 276.69 ng/ml (P-value <0.0012). As ACR increases mean NGAL increases significantly (P-value<0.05). CONCLUSION: Neutrophil gelatinase-associated lipocalin could be a renal function evaluation marker for patients with renal dysfunction and markers for detection of diabetic nephropathy in patients with type2 diabetes mellitus.
